Proceedings of the National Academy of Sciences · 15 September 2026 · From issue 37
Regulation of immune signal integration and memory by inflammation-induced chromosome conformation
In lab-grown immune cells, DNA folding lets past signals boost future immune responses.
Bence Daniel, Andy Y. Chen et al.
Immune cells called macrophages can remember a past chemical signal. They do this by folding their DNA into a new shape. This folding brings gene switches closer to the genes they control. As a result, the cell reacts faster and stronger the next time it meets a germ signal, even after the first signal is gone.
Shows DNA folding changes, not accessibility or histone marks, drive this memory effect in lab cells.
Lab-grown human immune cells only, no animal or patient data yet.
Integrity screen: passed (3 checks) Checked 16 September 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Proceedings of the National Academy of Sciences). Read the source
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