Proceedings of the National Academy of Sciences · 23 September 2026 · From issue 41
Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling
In mice, a gut sensor called NOD1 causes lasting gut and brain damage after infection.
Jungjae Park, Olivia Orahood et al.
Baby mice infected with a gut germ suffered damage that lasted into adulthood. The damage hit their gut lining, immune system, and even memory. A gut cell sensor called NOD1 caused this damage. Mice without this sensor stayed healthy. A natural substance from probiotic bacteria reduced the harm, without needing to kill the germ.
Shown only in infected newborn mice, not yet tested as a treatment in humans.
Mouse study only, no human data yet on this treatment.
Integrity screen: passed (3 checks) Checked 24 September 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Proceedings of the National Academy of Sciences). Read the source
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