Proceedings of the National Academy of Sciences·23 September 2026
In mice, a gut sensor called NOD1 causes lasting gut and brain damage after infection.
Baby mice infected with a gut germ suffered damage that lasted into adulthood. The damage hit their gut lining, immune system, and even memory. A gut cell sensor called NOD1 caused this damage. Mice without this sensor stayed healthy. A natural substance from probiotic bacteria reduced the harm, without needing to kill the germ.
Shown only in infected newborn mice, not yet tested as a treatment in humans.
Mouse study only, no human data yet on this treatment.
Integrity screen: passed (3 checks) Checked 24 September 2026. Jungjae Park, Olivia Orahood et al., Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling Read the source