BMJ · 23 July 2026 · From issue 11
Giving a drug within 12 hours cut serious kidney damage or death by about one third.
Tushar Shenoy, Daniel Sanchez-Almanzar et al., Early treatment with rasburicase and risk of kidney replacement therapy and death in adults with tumour lysis syndrome: emulated target trial, BMJ.
Some cancer treatments cause tumors to break down fast. This releases harmful substances into the blood, a problem called tumor lysis syndrome. In a study of 1276 hospital patients, giving a drug called rasburicase within 12 hours lowered the risk of severe kidney damage or death. It also lowered the risk of dying within 90 days.
Rate of severe kidney damage or death with early versus delayed drug treatment.
Observational study of 1276 patients, not a randomized trial.
Integrity screen: passed (3 checks) Checked 17 August 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (BMJ). Read the source
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