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Science  ·  1 October 2026  ·  From issue 45

Reframing menopause and menopause hormone therapy as opportunities for healthy aging

Menopause shapes long term health risks, and over 200 hormone therapy types each carry different risks and benefits.

Laura L. Gravelsins, Mateja Perović et al.

Menopause is a major body change that can bring up to 72 different symptoms. It affects health risks for the heart, bones, and brain for years afterward. This review argues that doctors need a more personal approach, since treatment options number over 200 types, each with its own risks and benefits based on dose and timing. It calls for care plans that factor in a woman's symptoms, genes, and past hormone use.

The number over 200 types

The number of different menopause hormone therapy varieties, each with its own risk and benefit mix.

Review of existing studies, not new trial data on any one treatment.

Integrity screen: passed (3 checks) Checked 6 October 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Science). Read the source

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