Nature Communications · 1 October 2026 · From issue 45

PrimPol toggled by ATR modulates fork slowing and repriming under oncogenic KRAS-induced replication stress

In lab cells, one protein switch controls whether stressed DNA copying slows down or restarts.

Taichi Igarashi, Takaaki Yasuhara et al.

Integrity screen: passed (3 checks) Checked 2 October 2026. Read the source

The plain-language reading of this paper is in the full issue, for subscribers.

Read the full issue

Get it free, every two days

Five papers free every issue, about 15 emails a month. No spam. Leave in one click.

Also in issue 45 15 papers

Menopause shapes long term health risks, and over 200 hormone therapy types each carry different risks and benefits.
Science
Alzheimer's disease and normal aging change two separate brain communication pathways, not one shared pathway.
Nature Neuroscience
In climate models, trade wind strength and warming sensitivity predict future eastern Pacific Ocean warming.
Science Advances
Ion exchange filtering causes less climate harm than carbon filtering, but short-chain PFAS removal costs more either way.
Nature Communications
Brain-attacking antibodies appear in kids with multiple sclerosis, with or without a common virus infection.
Proceedings of the National Academy of Sciences
In mice, a single molecular gate in fat cells controls fat burning based on time, diet, and temperature.
Science
Gene-editing prediction programs beat simple guessing once scientists fixed broken scoring tests.
Nature Biotechnology
People twist how much their choices help others, and selfish spin can spread to others.
Nature Human Behaviour
In flies, the ability to learn makes individual differences in behavior grow and persist.
eLife
A computer method sharpens microscope images and keeps faint molecular signals that older methods lose.
Science Advances
In mice, a brain region called the AHN drives extra sensitivity to stress after earlier hardship.
Nature
Negative mood pushed women with bulimia to favor taste over health in food choices faster than it did for others.
eLife
A faint carbon gas signal let scientists measure cosmic distances billions of light years away.
The Astrophysical Journal
In lab-grown infected cells, a human fat molecule sits inside the bacterium's packed DNA, then exits before activation.
Nature Communications