Proceedings of the National Academy of Sciences · 5 October 2026 · From issue 47

Recurrent hypermotif regulatory circuits in developmental programs

In human gut cells, the same five gene wiring patterns repeat again and again during organ growth.

Miri Adler, Ruslan Medzhitov.

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Also in issue 47 15 papers

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In mice, a gut receptor switch controls fat absorption and gut inflammation in opposite directions.
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In yeast cells, AI-picked antibody fragments blocked several snake toxins at once.
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In diseased kidneys, lopsided gene copy use in the filtering unit linked to better outcomes.
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Hard crystal pins between mineral layers let shellfish nacre stay stiff and resist cracking at once.
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Butterfly wing patterns team up with flapping flight to trick predators about their motion.
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A new sulfur-based salt builds carbon triangle shapes more safely than old explosive methods.
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