Science Advances · 2 October 2026 · From issue 47

Multiobjective V H H discovery through integrated high-throughput screening and AlphaFold3-guided structural prioritization

In yeast cells, AI-picked antibody fragments blocked several snake toxins at once.

Max D. Overath, Suthimon Thumtecho et al.

Integrity screen: passed (3 checks) Checked 6 October 2026. Read the source

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Also in issue 47 15 papers

In adults, a brain activity pattern formed during fear learning predicted fear's return after brain stimulation therapy.
Nature Communications
In tumor samples, three gene changes and three immune types mark cervical cancer in Chinese patients.
PLOS Biology
Adding iron to electrodes made water break apart faster to clean pollutants.
Nature Communications
In mice, a new glowing dye found more hidden ovarian tumors than the current best dye.
Science Advances
A new computer program sorts cells and blood samples by disease status from raw protein data.
Nature Communications
The worst drought in 2,000 years happened during a cool period, not a hot one.
Proceedings of the National Academy of Sciences
A model using cause-and-effect chemical maps predicts toxic effects better than shape-only models.
Proceedings of the National Academy of Sciences
A dusty star disk swaps its bright and dark sides depending on the light used.
The Astrophysical Journal
In human gut cells, the same five gene wiring patterns repeat again and again during organ growth.
Proceedings of the National Academy of Sciences
In mice, a gut receptor switch controls fat absorption and gut inflammation in opposite directions.
eLife
In diseased kidneys, lopsided gene copy use in the filtering unit linked to better outcomes.
Science Advances
Hard crystal pins between mineral layers let shellfish nacre stay stiff and resist cracking at once.
Science
Butterfly wing patterns team up with flapping flight to trick predators about their motion.
Nature
A new sulfur-based salt builds carbon triangle shapes more safely than old explosive methods.
Nature