Proceedings of the National Academy of Sciences · 18 August 2026 · From issue 23

Human Hsp70 paralogs display selective J-domain interactions tuning proteostasis under stress

Four related cell repair proteins have different jobs, not just backup copies of each other.

Roni Suhler, Lars J. W. van Beurden et al.

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Also in issue 23 15 papers

Certain gut bacteria in lung tumors boost a warning signal that activates immune cells.
Proceedings of the National Academy of Sciences
A muscle-made substance called BAIBA helps control muscle strength and exercise ability in mice.
Nature Communications
Rivers overflow their banks at very different rates depending on climate, not every two years.
Nature Communications
Non-communicable diseases got only 2.5% of health aid despite causing 59.5% of lost healthy years worldwide.
Nature Communications
In mice, slow nasal airflow calms anxiety by activating a specific brain pathway.
Proceedings of the National Academy of Sciences
In worms, each host species blocks a virus in a different way, stopping it from spreading.
PLOS Biology
A reusable molecule attaches ring-shaped chemical groups to ketones with pinpoint accuracy.
Nature Chemistry
Mountain plant shifts toward warmth match regional warming, but not at individual plot level.
Nature Ecology & Evolution
Focusing on a skin reaction shrank immune responses by about 1.5 times compared to distraction.
Nature Human Behaviour
A new catalog measures heat, gravity, and chemistry for over 24,000 stars using computer models.
The Astrophysical Journal
A missing nuclear measurement finally explains excess rare metal found in ancient star dust.
Physical Review Letters
Adults with severe intellectual disability died at a median age of 57.9 years, 24 years earlier than the general public.
PLOS Medicine
In zebrafish, a mitochondria-protecting drug raised survival and eased liver damage from a rare genetic disease.
Science Advances
In mice, fear, food value, and social rank together steer fast survival decisions.
eLife

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