Nature Communications · 27 July 2026 · From issue 12
In mice, an antibody treatment for tumors fails without a working internal immune sensor.
Yueyun Pan, Shengduo Pei et al., Cancer immunotherapy targeting murine myeloid cells requires endosomal pattern recognition, Nature Communications.
In mice, a cancer immune treatment only worked when certain immune cells had a working internal sensor. This sensor sits inside the cell and detects foreign signals. It switches on genes that fight tumors. Without this sensor, treatment failed and tumor supporting immune cells stayed unhelpful.
Shows a specific internal alarm system in immune cells is needed for the treatment to work in mice.
Mice only, no human data yet.
Integrity screen: passed (3 checks) Checked 28 July 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Nature Communications). Read the source
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