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eLife  ·  2 September 2026  ·  From issue 31

Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome

Movie-watching brain scans predict memory skills better than resting brain scans do.

Morteza Esmaeili, Erin Beate Bjørkeli et al.

Brain scans taken while people watch a movie predict memory skills better than scans taken while resting. Scientists also found a gap between what a brain scan predicts and what a person actually scores. People whose real memory beat their brain's prediction moved more and had healthier hearts. Lower dopamine levels, a brain chemical tied to motivation and reward, linked to bigger gaps between prediction and actual performance.

What it could change A brain scan gap links to lower activity, heart risk, and dopamine levels.

Shows a link, not proof, between brain scan predictions and health factors.

Observational human data only, cannot prove dopamine causes the gap.

Integrity screen: passed (3 checks) Checked 4 September 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (eLife). Read the source

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