Proceedings of the National Academy of Sciences · 1 September 2026 · From issue 30

A multispecies toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage

In yeast, mice, and human cells, altered proteins caused far more DNA breaks and more cell death.

David Ontoso, Monika Mehta et al.

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Also in issue 30 15 papers

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In mice, a specific brain circuit controls how fast antidepressant treatments work.
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Water waves flowed almost untouched through a specially patterned messy surface instead of scattering.
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A computer program calculates how easily each tiny part of a protein opens, even in huge proteins.
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In plants, a cell scaffolding protein has a hidden second job turning on defense genes.
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In mice, social rank stays stable even when group members change.
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Unarmed civilian safety workers cut crime at San Francisco intersections without using police force.
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In rats, estrogen reduced fatty liver damage caused by low testosterone and a bad diet.
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A math model tracking real-time events ranks influence better than fixed, static network scores.
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In a lab experiment, twisted laser light let scientists steer electric currents inside a carbon sheet.
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Children of mothers with severe obesity had nearly double the risk of early death.
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Solar farms in northern China's deserts also cut nearby dust air pollution, a computer model shows.
Geophysical Research Letters
In a solar simulation, a sun jet appears to fade just because it breaks into threads too thin to see.
The Astrophysical Journal

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