PLOS Biology·10 August 2026
In mice, two gene switches normally curb harmful immune cells but fail inside inflamed brain tissue.
Two tiny molecules that control genes help hold back harmful immune cells, and this control breaks down during brain inflammation. In mice with a multiple sclerosis like disease, scientists mapped which small gene switches turn on in different types of immune helper cells. They found 110 of these switches differ between inflammatory cells and calming regulatory cells. Two of them, when studied closely, changed how fast inflammatory cells multiplied and how they matured, affecting how severe the disease became.
The number of small gene switches found to differ between inflammatory and calming immune cells in mice.
Mouse model only, no human data yet.
Integrity screen: passed (3 checks) Checked 17 August 2026. Carolina Cunha, Daniel Inácio et al., A microRNA atlas of CD4+ T cell subsets in experimental autoimmune encephalomyelitis identifies regulators of disease pathogenesis Read the source