PNAS Nexus · 6 October 2026 · From issue 48
Soluble Siglec-9 combined with exercise ameliorates HFD-induced metabolic and depressive-like phenotypes with gut-brain axis changes
In mice, a protein plus exercise reduced depression-like behavior caused by a fatty diet.
Kohki Matsubara, Shintaro Tsukada et al.
In mice, a natural anti-inflammatory protein combined with exercise eased depression-like symptoms caused by a fatty diet. The protein calmed swollen brain cells and helped new brain cells grow in a memory area. It also shifted gut bacteria toward healthier types that produce helpful byproducts. Mice fed the diet for 8 weeks, then treated for 4 more weeks, showed the biggest improvement when the protein and exercise were used together.
Based on mouse brain, gut bacteria, and behavior tests, not human trials.
Mice only, four week treatment, no human testing yet.
Integrity screen: passed (3 checks) Checked 20 October 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (PNAS Nexus). Read the source
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