PNAS Nexus · 24 October 2026 · From issue 57
Single-cell heterogeneity of adipose eosinophils is shaped by sex and RELMα and linked to macrophage communication networks in obesity
In mice, fat tissue immune cells called eosinophils split into six types shaped by sex and a protein.
Rebecca E Ruggiero-Ruff, Xinru Qiu et al.
Fat tissue immune cells called eosinophils come in six different types in mice, not just one. Which types show up depends on sex, worm infection, and a protein called RELMα. Female mice and worm-infected mice have more calming, protective eosinophil types. Male mice and mice without RELMα have more inflammatory types, with different signals passing to another immune cell called macrophages.
The number of distinct eosinophil cell types found in mouse fat tissue.
Mice only, no human data yet.
Integrity screen: passed (3 checks) Checked 30 October 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (PNAS Nexus). Read the source
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