Science · 24 September 2026 · From issue 43

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

In mice, targeted nanoparticles shrank tumor scarring and restored immune attack on cancer.

Clemens Hinterleitner, Valentin J. A. Barthet et al.

Scars can hide tumors from the immune system and block cancer treatment. In mice, tiny particles built to find a marker on aging, damage-causing cells cut scarring and woke up immune cells inside tumors. This let the tumors respond better to immune-boosting drugs.

What it could change In mice, nanoparticles that target aging scar-forming cells reduced tumor scarring and helped immune cells fight the cancer better.

Shows the treatment worked in mouse tumors, not yet tested in humans.

Mice only, no human data yet.

Integrity screen: passed (3 checks) Checked 30 September 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Science). Read the source

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