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In this issue 15 papers · 5 free

01 Science Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer Free
02 Geophysical Research Letters Unprecedented Open‐Ocean Polynya in Breid Bay, East Antarctica in Winter 2024 Free
03 Nature Communications Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors in mice Free
04 Nature Communications Alteromonas macleodii breaches the diatom frustule triggering protoplast emergence and programmed necrosis-like death in Thalassiosira rotula Free
05 Science Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates Free
06 Monthly Notices of the Royal Astronomical Society CNN+FoF: application of deep learning to the identification of dark matter haloes Subscribers
07 Nature Communications Reaction enhancement via product scavenging and phase separation-driven pathway canalization Subscribers
08 Geophysical Research Letters Photochemical Aging of Atmospheric Black Carbon Promotes Nitrate Coating in a Chinese Megacity Subscribers
09 Proceedings of the National Academy of Sciences Dynamic attribute activation explains gaze biases in choice Subscribers
10 Proceedings of the National Academy of Sciences Analytic nonlinear theory of shear banding in amorphous solids Subscribers
11 Proceedings of the National Academy of Sciences An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss Subscribers
12 Science Advances Pliny the Younger advances geochronology Subscribers
13 Science Advances Aqueous lignin adhesive for high-performance wood bonding Subscribers
14 Science Advances Self-organized optofluidic locking enables stable single-frequency lasing in dynamic liquid media Subscribers
15 Science Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes Subscribers

The papers Read free

Science·24 September 2026

Clemens Hinterleitner, Valentin J. A. Barthet et al.

In mice, targeted nanoparticles shrank tumor scarring and restored immune attack on cancer.

Scars can hide tumors from the immune system and block cancer treatment. In mice, tiny particles built to find a marker on aging, damage-causing cells cut scarring and woke up immune cells inside tumors. This let the tumors respond better to immune-boosting drugs.

What it could change In mice, nanoparticles that target aging scar-forming cells reduced tumor scarring and helped immune cells fight the cancer better.

Shows the treatment worked in mouse tumors, not yet tested in humans.

Mice only, no human data yet.

Integrity screen: passed (3 checks) Checked 30 September 2026. Clemens Hinterleitner, Valentin J. A. Barthet et al., Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer Read the source

Geophysical Research Letters·27 September 2026

Jeebanjyoti Swain, Babula Jena et al.

In Antarctica, storms and rising warm water opened a huge hole in winter sea ice.

A giant hole opened in the winter sea ice near Antarctica in August 2024. It covered about 89,121 square kilometers of open ocean, an area bigger than many countries. Six powerful storms carried warm, wet air toward Antarctica and stopped new ice from forming. At the same time, warm ocean water rose up from below and heated the surface by about 0.6 degrees Celsius, melting even more ice.

The number 89,121 square kilometers

The size of the open-ocean hole that formed in Antarctic winter sea ice in August 2024.

One event, one location, one winter studied so far.

Integrity screen: passed (3 checks) Checked 30 September 2026. Jeebanjyoti Swain, Babula Jena et al., Unprecedented Open‐Ocean Polynya in Breid Bay, East Antarctica in Winter 2024 Read the source

Nature Communications·26 September 2026

Michael W. Gongwer, Fanny Etienne et al.

In mice, missing brain cleanup cells cause lasting changes in threat response behavior.

Brain cells called microglia do more than clean up unused connections. They also help build new connections in a brain area that controls emotions and motivation. In mice born without microglia, this area formed fewer new connections early in life. This led to lasting changes in how the mice reacted to threats, even as adults.

What it could change Mice without microglia grew fewer new brain connections and later avoided threats differently.

Shows microglia help build brain connections, not just remove them, in a mouse emotion center.

Mice only, early life findings, no human data yet.

Integrity screen: passed (3 checks) Checked 28 September 2026. Michael W. Gongwer, Fanny Etienne et al., Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors in mice Read the source

Nature Communications·26 September 2026

Isobel Short, Clara Martínez-Pérez et al.

A common ocean bacteria breaks open diatom shells, killing over 95% of cells within 72 hours.

A common ocean bacteria can break open the hard glass-like shell of a tiny algae called a diatom. Within 72 hours, more than 95% of the algae cells were forced out of their broken shells and left exposed. Once outside, the naked cells died in a controlled way, similar to how damaged cells self destruct in other living things. At the same time, the bacteria turned on genes for swimming toward and feeding on the dying algae.

The number over 95%

The share of diatom cells forced out of their broken shells within 72 hours in lab tests.

Lab cultures only, not open ocean, no real-world rate shown.

Integrity screen: passed (3 checks) Checked 28 September 2026. Isobel Short, Clara Martínez-Pérez et al., Alteromonas macleodii breaches the diatom frustule triggering protoplast emergence and programmed necrosis-like death in Thalassiosira rotula Read the source

Science·24 September 2026

Pu Gao, Ellen J. Pritham et al.

A jumping brain gene copied itself into a human wart virus and still moves today.

A brain gene called BC200 helps nerve cells build proteins. But this gene also has a second life: it keeps copying itself and jumping to new spots in the DNA of humans and other primates, something scientists thought had stopped long ago. Scientists found two copies of this gene inside a virus that causes a human wart-like skin infection. This shows the gene had jumped straight from a person's cells into the virus itself.

The number two copies

The number of times this brain gene was found inserted inside a human wart virus's DNA.

Genetic analysis only, no health effects tested yet.

Integrity screen: passed (3 checks) Checked 30 September 2026. Pu Gao, Ellen J. Pritham et al., Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates Read the source

10 more papers are in the full issue.

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Monthly Notices of the Royal Astronomical Society·26 September 2026

Soumadeep Maiti, Carlos M Correa et al.