Nature · 9 September 2026 · From issue 34
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
In mice, blocking a lymph node molecule let immune cells fight tumors much better.
Anneloes van Krimpen, Julie Huang et al.
A substance made by immune cells in lymph nodes near tumors can stop the body from fighting cancer well. These lymph nodes sit close to tumors and normally help train defender cells called T cells. Blocking this substance let T cells grow and multiply, and in mice this shrank tumors. Pairing this block with an existing cancer drug worked even better in mice given human immune cells.
Shown in mice and lab studies, not yet tested as a cancer treatment in people.
Mouse and lab study only, no human treatment data yet.
Integrity screen: passed (3 checks) Checked 16 September 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Nature). Read the source
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