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Nature Medicine  ·  15 June 2026  ·  From issue 00

Deep brain stimulation that decodes what a Parkinson’s patient is doing in real time and adapts to it improved walking while preserving control of other motor symptoms.

Stefano Scafa, Valeria de Seta, Ruijia Wang, Paula Sánchez López et al., Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease, Nature Medicine.

Deep brain stimulation helps people with Parkinson’s, but it usually runs at fixed settings that ignore what the person is doing moment to moment. Researchers found they could read the ongoing activity, such as walking, directly from brain signals in a region called the subthalamic nucleus, and use that to adjust the stimulation in real time. This activity aware approach improved walking problems while keeping the benefits for other core motor symptoms.

Integrity screen: passed (3 checks) Checked 3 July 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Nature Medicine). Read the source

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