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In this issue 15 papers · 5 free

01 Nature Communications A CCL21 gene-modified dendritic cell vaccine combined with pembrolizumab in advanced non-small cell lung cancer: a phase I trial Free
02 Geophysical Research Letters Dust Loading Increases During Topsoil Flash Droughts Under Rapid Surface Drying and Vegetation Stress Free
03 Nature Communications Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses Free
04 Nature Human Behaviour Intrinsic rewards guide visual resource allocation via reinforcement learning Free
05 Proceedings of the National Academy of Sciences Deep learning of fossil pollen morphology reveals 25,000 y of ecological change in eastern African grasslands Free
06 Proceedings of the National Academy of Sciences PAK4 exacerbates melanoma immunosuppression by promoting exosome release Subscribers
07 Science Advances In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations Subscribers
08 Nature Scalable decision-making for games of imperfect information Subscribers
09 The Astrophysical Journal Aberration/Retardation Analysis of PSR B1451-68’s Profiles from Decimeter to Meter Wavelengths: Emission Heights and Implications for ‘Radius-to-Frequency Mapping’ Subscribers
10 Nature Ecology & Evolution A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape Subscribers
11 Nature Communications Thermally programmed disassembly and reconstruction of 2D polymer platelets via melting-governed crystallization-driven self-assembly Subscribers
12 Nature Chemistry A crystalline uranium Fischer-type carbyne Subscribers
13 Science Verification makes discovery matter Subscribers
14 Science Keep AI-augmented science contestable Subscribers
15 Geophysical Research Letters Magnetic Imaging of the Effect of Stress on the Remanent Magnetization of Basalt Subscribers

The papers Read free

Nature Communications·4 October 2026

Michael S. Oh, Aaron E. Lisberg et al.

A lung cancer vaccine plus immune drug brought immune cells into tumors but did not shrink them.

A combination treatment for advanced lung cancer did not shrink tumors in a small trial of 23 patients. The treatment paired an immune-boosting vaccine made from a patient's own cells with a cancer drug already used to help the immune system fight tumors. It was safe to use. It brought more immune cells into tumors, but those cells often did not stick around or fight the cancer well.

The number 0 of 23 patients responded

The share of patients whose tumors actually shrank in this small safety trial.

Only 23 patients, early-phase safety trial, not a proven treatment.

Integrity screen: passed (3 checks) Checked 4 October 2026. Michael S. Oh, Aaron E. Lisberg et al., A CCL21 gene-modified dendritic cell vaccine combined with pembrolizumab in advanced non-small cell lung cancer: a phase I trial Read the source

Geophysical Research Letters·3 October 2026

Xuesong Wang, Chunlai Zhang et al.

Dust levels rose over nearly half of studied land during fast topsoil drying events.

Fast-drying topsoil, called a flash drought, often comes with more dust in the air. Nearly half of the land checked showed higher dust levels during these quick dry spells. Low soil moisture, dry background weather, and stressed plants mattered more for dust levels than wind speed did. The study cannot prove that flash droughts cause the extra dust, since other changing conditions could play a role too.

The number 44.7% of land pixels

The share of checked land that had more dust in the air during quick topsoil dry spells.

Satellite data only, from 2003-2022, cannot prove cause and effect.

Integrity screen: passed (3 checks) Checked 6 October 2026. Xuesong Wang, Chunlai Zhang et al., Dust Loading Increases During Topsoil Flash Droughts Under Rapid Surface Drying and Vegetation Stress Read the source

Nature Communications·4 October 2026

Xun Feng, Lunzhi Yuan et al.

In mice, a three-armed flu drug clumped viruses together and beat existing long-acting drugs.

Scientists built a new kind of flu drug by attaching three copies of an antiviral molecule to one carrier protein. This three-armed design makes the drug grip flu virus particles from several sides at once, clumping viruses together. In mice with different flu strains, including bird flu, this clumped version worked better and lasted longer than older long-acting flu drugs. The study shows that how many copies of the drug you attach changes how the drug fights the virus.

What it could change A three-armed drug design made flu viruses stick together, blocking them from entering and leaving cells.

Shown in mice infected with several flu strains, including bird flu, not yet tested in humans.

Mouse study only, no human data yet.

Integrity screen: passed (3 checks) Checked 4 October 2026. Xun Feng, Lunzhi Yuan et al., Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses Read the source

Nature Human Behaviour·1 October 2026

Ivan Tomić, Rodrigo Raimundo et al.

People focus more on tasks that already feel easy, making hard tasks even harder.

People pay more attention to things that already make them feel sure of themselves. This happens even when there is no money or prize at stake. In vision experiments, people got better at judging things they already judged well. They got worse at judging things they already judged poorly. A computer model combining brain attention rules with a simple reward-learning rule matched these results closely.

What it could change A feeling of confidence alone can shift how the brain spends its attention.

Shows that a sense of being right, not just real rewards, biases visual attention in lab tasks.

Lab vision tasks only, no sample size given in the abstract.

Integrity screen: passed (3 checks) Checked 6 October 2026. Ivan Tomić, Rodrigo Raimundo et al., Intrinsic rewards guide visual resource allocation via reinforcement learning Read the source

Proceedings of the National Academy of Sciences·2 October 2026

Marc-Élie Adaimé, Shu Kong et al.

A computer program tracked grass pollen shapes to reveal 25,000 years of ecosystem change.

A computer program learned to spot tiny shape differences in grass pollen that look almost the same under a normal microscope. It studied super sharp images of pollen from a lake near Mount Kenya, covering 25,000 years of history. The program tracked how many grass species lived there over time and whether they used a heat tolerant or cooler weather strategy to grow. Grass diversity dropped a lot between 21,500 and 16,000 years ago, during the coldest part of the last ice age. After the ice age ended, heat loving grasses slowly became less common as the climate warmed and fires happened less often.

The number 25,000 years

The span of fossil pollen record analyzed from a lake near Mount Kenya.

One lake site in Kenya studied, lab based image analysis only.

Integrity screen: passed (3 checks) Checked 4 October 2026. Marc-Élie Adaimé, Shu Kong et al., Deep learning of fossil pollen morphology reveals 25,000 y of ecological change in eastern African grasslands Read the source

10 more papers are in the full issue.

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Proceedings of the National Academy of Sciences·2 October 2026

Ruizhi Zhou, Tong Xu et al.