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In this issue 15 papers · 5 free

01 Nature Medicine Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC Free
02 Nature Communications Widespread declines of formerly common species reshape local assemblages over time Free
03 Science Glycan recognition by a plant damage-sensing immune receptor Free
04 Nature Communications Reinterpreting precipitation isotope records from Asian monsoon region through the hidden role of atmospheric updraft Free
05 Nature Communications The 11-hydroxy-jasmonic acid pathway expands jasmonate catabolic repertoire for stress-specific hormone attenuation in Arabidopsis Free
06 Proceedings of the National Academy of Sciences Why did some viruses evolve to be giants while others did not? Subscribers
07 The Astrophysical Journal Statistical Analysis of Coronal Hole Spatiotemporal Evolution, Kinematics, and Lifetimes over 1.5 Solar Cycles Subscribers
08 Physical Review Letters First Energy-Scan Measurement of e + e - → K + K - around the ψ ( 2 S ) Resonance Subscribers
09 Proceedings of the National Academy of Sciences Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence Subscribers
10 Science Advances A highly sensitive and drift-free iontronic sensor enabled by a polarity-balanced polyelectrolyte for surgical force sensing Subscribers
11 Science Advances Mutant p53 sensitizes KRAS-driven lung adenocarcinoma to immunotherapy by repressing SPP1 Subscribers
12 Science Advances Direct metathesis deconstruction to recycle poly(dicyclopentadiene) composites Subscribers
13 Science In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia Subscribers
14 Nature Neuroscience Representational learning by optimization of neural manifolds in an olfactory memory network Subscribers
15 eLife PRRT2 as an auxiliary regulator of Nav channel slow inactivation Subscribers

The papers Read free

Nature Medicine·1 September 2026

Arsela Prelaj, Vanja Miskovic et al.

An AI tool using blood and health data helped doctors predict immunotherapy response in lung cancer better than standard scores.

An AI tool built from blood tests and basic health records helped doctors predict how lung cancer patients respond to immune-based treatment. The tool used data from 2,396 patients and worked better than older methods like standard cancer markers or general health scores. Adding scan images and tissue samples made the tool look better in early tests. But this benefit did not clearly hold up when tested on different patient groups.

The number 0.77 AUC

The AI model's accuracy score in predicting immunotherapy response, in its own test group of patients.

2,396 patients studied, but accuracy dropped in outside patient groups.

Integrity screen: passed (3 checks) Checked 6 October 2026. Arsela Prelaj, Vanja Miskovic et al., Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC Read the source

Nature Communications·12 September 2026

Weiqiang Xu, Junfeng Gao et al.

Once-common species are declining faster than rare species on land and at sea.

Species that used to be common are shrinking in number faster than rare species. This pattern shows up on land and in the ocean. Freshwater habitats do not show a clear pattern either way. New species moving into an area help offset losses in the rarest groups, but common species keep losing ground overall.

The number 4,748 sites, 129 studies

The scale of the data used to compare trends in common versus rare species.

Past-data analysis only, cannot prove why common species decline faster.

Integrity screen: passed (3 checks) Checked 14 September 2026. Weiqiang Xu, Junfeng Gao et al., Widespread declines of formerly common species reshape local assemblages over time Read the source

Science·10 September 2026

Pedro Jiménez-Sandoval, Owen Kentish et al.

A plant protein has a pocket shaped to grab broken bits of chewed-up cell walls.

Germs attack plants by breaking down the tough wall around each cell. Scientists mapped the shape of a plant sensor protein and found it has a pocket built to grab a specific sugar piece. This piece comes from cellulose, the main material in plant walls, and appears when the wall gets damaged. The sensor's shape lets it tell apart tiny differences in these sugar pieces, so it can spot real damage and warn the plant.

What it could change A plant sensor protein can spot broken wall fragments as a sign of attack.

Shows the sensor's shape and its grip on a wall-damage sugar piece, not field disease outcomes.

Lab structure study only, no field infection data shown.

Integrity screen: passed (3 checks) Checked 16 September 2026. Pedro Jiménez-Sandoval, Owen Kentish et al., Glycan recognition by a plant damage-sensing immune receptor Read the source

Nature Communications·11 September 2026

Zhuanxia Zhang, Wusheng Yu et al.

Rising air, not wind-blown moisture, mainly controls oxygen patterns in Asian monsoon rain.

Cave rock records help scientists study ancient monsoons. But reading these records depends on knowing what controls oxygen patterns in today's rain. Data from 46 rain sites across the Asian monsoon region show that low oxygen values move slowly from east to west each season. This movement lines up with rising air and storm activity, not just wind blowing in moisture, as many had assumed before.

The number 46 sites

The number of rain measurement locations used to track oxygen patterns across the Asian monsoon region.

Rain data only, no direct test on cave rock records yet.

Integrity screen: passed (3 checks) Checked 14 September 2026. Zhuanxia Zhang, Wusheng Yu et al., Reinterpreting precipitation isotope records from Asian monsoon region through the hidden role of atmospheric updraft Read the source

Nature Communications·12 September 2026

Thierry Heitz, Valentin Marquis et al.

In Arabidopsis plants, one enzyme family makes a different breakdown product of a stress hormone than scientists thought.

Plants make a stress hormone that shifts their energy from growing to defending. This hormone must be broken down at the right time, or its defense signal lasts too long. Scientists in this study found that one set of plant enzymes makes a different breakdown product than experts had assumed for years. The plant uses one breakdown path after a physical wound and a different path after a fungal infection.

What it could change A new breakdown path for a plant stress hormone, active only during fungal attack, not wounding.

Shows the plant uses different chemical routes depending on whether it is wounded or infected.

Lab plant only, no crop or human relevance shown yet.

Integrity screen: passed (3 checks) Checked 14 September 2026. Thierry Heitz, Valentin Marquis et al., The 11-hydroxy-jasmonic acid pathway expands jasmonate catabolic repertoire for stress-specific hormone attenuation in Arabidopsis Read the source

10 more papers are in the full issue.

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Proceedings of the National Academy of Sciences·11 September 2026

Eugene V. Koonin, Mart Krupovic