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In this issue 15 papers · 5 free

01 Nature Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers Free
02 Science A commensally regulated immune rheostat fine-tunes skin barrier fitness Free
03 Geophysical Research Letters Important but Overlooked Reactive Organic Carbon (ROC) Air Pollution From Permafrost Wildfires in Canada Free
04 Science Advances Depressed chemical weathering inhibited climate stabilization after the end-Permian biocrisis Free
05 Science The global geography of threats to freshwater biodiversity Free
06 Nature Communications CryoET imaging reveals that mitotic spindles are locally organized by microtubule density and Eg5 activity Subscribers
07 Proceedings of the National Academy of Sciences Ddx3x deficiency in mice impairs corticofugal motor circuits and causes motor deficits that are attenuated by early-life exercise Subscribers
08 Proceedings of the National Academy of Sciences Potential energy landscape networks of confined vortex matter Subscribers
09 Proceedings of the National Academy of Sciences Direct atomic-scale observation reveals rare earth element fractionation at mineral-water interfaces Subscribers
10 Science Intrinsic gestational timing governs human cerebellar development after preterm birth Subscribers
11 Nature Spatial and sectoral water demand assessment for the African continent Subscribers
12 Nature Stone and water governed early human settlement of the desert Subscribers
13 Nature Communications Thrombin reshapes α-synuclein biochemical properties by N-terminal truncation Subscribers
14 PLOS Medicine Immunogenicity and safety of Institut Pasteur du Cambodge (IPC) and updated Thai Red Cross (UTRC) intradermal rabies vaccine regimens among healthy adults in India: A phase 4, open label, equivalence randomised controlled trial Subscribers
15 The Astrophysical Journal The Emergence of X-Ray Emission Lines during Relativistic Radio-jet Formation in the Changing-look Active Galactic Nucleus 1ES 1927+654 Subscribers

The papers Read free

Nature·28 October 2026

Eliza Yankova, Alexandra Sapetschnig et al.

In mice and lab cells, a new drug shrank tumors by blocking a protein-building enzyme.

A new drug called STM9005 blocks an enzyme cancer cells need to build proteins. The enzyme normally tags tiny molecules that cells use as instructions for making proteins. In lab-grown cancer cells, the drug stopped growth. In mice with cancer, it shrank tumors and helped them live longer.

What it could change A drug blocking a protein-building enzyme shrank tumors and extended survival in several mouse cancer models.

Shown only in lab cells and mice, across cancers like leukemia, melanoma, and lung cancer.

Mice and lab cells only, no human trials yet.

Integrity screen: passed (3 checks) Checked 30 October 2026. Eliza Yankova, Alexandra Sapetschnig et al., Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers Read the source

Science·29 October 2026

Anita Gola, Rohith Srinivas et al.

In mice, immune cells in skin release a signal that controls stem cell growth and barrier strength.

Special immune cells in mouse skin act like a dial that controls how fast skin stem cells grow. These cells release a chemical signal that tells stem cells to slow down and finish turning into tough, protective skin. When this signal is blocked, stem cells grow too fast and skin cannot build a strong barrier. The immune cells adjust the signal based on the germs normally living on the skin.

What it could change A skin immune signal keeps stem cells from overgrowing and weakening the skin barrier.

Shows how immune cells and skin germs together control stem cell activity in mouse skin.

Mice only, no human skin data yet.

Integrity screen: passed (3 checks) Checked 30 October 2026. Anita Gola, Rohith Srinivas et al., A commensally regulated immune rheostat fine-tunes skin barrier fitness Read the source

Geophysical Research Letters·28 October 2026

Xueying Liu, Zejiang Yu et al.

In Canada's 2023 fires, small gas emissions caused large spikes in toxic air pollution.

Permafrost wildfires in Canada burn both surface plants and deep soil. This releases gases that are a small part of the smoke, but they still make air pollution worse. During the record 2023 fire season, these gases raised levels of toxic chemicals like benzene and formaldehyde. They also helped create most of the extreme smog measured that year.

The number 15 ± 8 million tons of carbon

The amount of gas emissions from 2023 Canadian wildfires that still drove most of the record smog.

Model and inventory based estimates, not direct human health measurements.

Integrity screen: passed (3 checks) Checked 30 October 2026. Xueying Liu, Zejiang Yu et al., Important but Overlooked Reactive Organic Carbon (ROC) Air Pollution From Permafrost Wildfires in Canada Read the source

Science Advances·30 October 2026

Guang-Yi Wei, Feifei Zhang et al.

Loss of deep-rooted plants weakened a natural process that pulls carbon dioxide from the air.

About 252 million years ago, a huge extinction killed most life on Earth. It wiped out deep-rooted plants that once helped cool the planet. Scientists studied ancient rock chemistry and found that land rocks stopped soaking up carbon dioxide as well after this die-off. This kept the planet hot for a long time and slowed recovery of ocean and land life.

What it could change Dying forests weakened Earth's natural cooling system for millions of years.

Based on ancient rock chemistry and a climate model, not a live experiment.

Ancient rock data and model only, 252 million years ago.

Integrity screen: passed (3 checks) Checked 30 October 2026. Guang-Yi Wei, Feifei Zhang et al., Depressed chemical weathering inhibited climate stabilization after the end-Permian biocrisis Read the source

Science·29 October 2026

Christophe Brabant, Laura Pollock et al.

Freshwater animals face more overlapping threats than land animals, especially near dams and cities.

A huge mapping project tracked 45 threats to over 21,000 freshwater species. These include frogs, fish, mammals, dragonflies, and reptiles. Areas with heavy human development and water control, like dams, have the most overlapping threats. Freshwater species face more intense threats and different danger patterns than land animals.

The number 21,490 species

The number of freshwater species mapped against 45 types of threats worldwide.

Global mapping study only, not a test of direct cause.

Integrity screen: passed (3 checks) Checked 30 October 2026. Christophe Brabant, Laura Pollock et al., The global geography of threats to freshwater biodiversity Read the source

10 more papers are in the full issue.

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Nature Communications·29 October 2026

William Conway, Daija Bobe et al.