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In this issue 15 papers · 5 free

01 Science Advances A clinical and experimental investigation of liraglutide effects on the brain-kidney axis Free
02 Science Decadal doubling of Siberian methane emissions due to warming-induced fires and methanogenesis Free
03 Nature Genetics High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk Free
04 Nature Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours Free
05 Nature Human Behaviour Longitudinal effect of early social media use on standardized learning outcomes during school career Free
06 Nature Nanotechnology Spectral biophysical cytometry with nanosensors reveals remodelling of immune cells in atherosclerosis Subscribers
07 Monthly Notices of the Royal Astronomical Society An Agnostic Machine Learning Model of Photosynthetic Habitability Subscribers
08 Nature Communications Dilute electrolytes for suppressing metal anode corrosion during calendar aging and cycling in aqueous zinc batteries Subscribers
09 Nature Medicine Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial Subscribers
10 Science A central role for dietary sugars in human evolution Subscribers
11 PNAS Nexus The pivotal role of the food service industry in alleviating urban segregation and boosting city vitality Subscribers
12 Nature Communications In situ electron microscopy of LaNiO3 transformation during reduction and methane dry reforming Subscribers
13 Science Advances Assessing pedestrian responses to autonomous and personal mobility robots in crowded public spaces Subscribers
14 Science Advances Steppe productivity decline contributed to smallpox outbreak and the collapse of the last nomadic empire in the 1750s Subscribers
15 Nature Communications Nuclear exosome targeting complexes modulate cohesin binding and enhancer-promoter interactions in 3D Subscribers

The papers Read free

Science Advances·7 August 2026

Michael P. Greenwood, Mohammed I. Alotaibi et al.

Liraglutide lowers a key water balancing hormone in healthy people and changes related proteins in rats.

A diabetes and weight loss drug called liraglutide lowers a hormone that helps the body hold onto water. This hormone is called vasopressin. In healthy people, the drug reduced blood levels of this hormone. In rats, the drug changed proteins inside the brain gland that makes this hormone. These changes were different in males and females. The drug also changed a water channel in the kidney that responds to this hormone.

What it could change A weight loss drug was shown to lower a hormone that controls body water and blood pressure.

Shown in healthy human volunteers and in rat brain and kidney tissue, not in patients with disease.

Small human trial plus rat experiments only, not a patient outcome study.

Integrity screen: passed (3 checks) Checked 11 August 2026. Michael P. Greenwood, Mohammed I. Alotaibi et al., A clinical and experimental investigation of liraglutide effects on the brain-kidney axis Read the source

Science·6 August 2026

Sihong Zhu, Yi Liu et al.

Siberian methane emissions grew 12 teragrams from 2010 to 2023, driven by fires and wet soil.

Methane gas released from Siberia's frozen ground and wetlands during the growing season jumped by 12 teragrams between 2010 and 2023. That is about 5% more each year. Warmer, drier weather in eastern Siberia caused more wildfires, which released methane. Wetter weather in western Siberia caused wetlands to release more methane too. By 2050, this rising Siberian methane could cancel out about 20% of the global methane cuts needed to meet climate goals.

The number 12.0 teragrams of methane

The rise in Siberian growing-season methane emissions measured between 2010 and 2023.

Air measurements over one region, projection to 2050 is uncertain.

Integrity screen: passed (3 checks) Checked 13 August 2026. Sihong Zhu, Yi Liu et al., Decadal doubling of Siberian methane emissions due to warming-induced fires and methanogenesis Read the source

Nature Genetics·1 August 2026

Valeriya Malysheva, Helen Ray-Jones et al.

A DNA folding map in human immune cells links gut disease risk genes to specific gene switches.

Immune cells called type 3 innate lymphoid cells help protect body linings like the gut, but scientists know little about how their genes get switched on. Researchers mapped the physical loops that DNA forms inside these cells, showing which distant DNA switches control which genes. This map linked known Crohn's disease risk spots to new candidate genes, including one already known to cause a rare childhood brain disease. When that same gene was boosted in mouse immune cells, it changed how the cells reacted to stimulation and which signaling chemicals they released.

What it could change A gene tied to a rare brain disease also shapes immune cell activity linked to Crohn's disease risk.

Shown only in mouse immune cells in the lab, not confirmed in human patients.

Mouse cell line only, no human patient data yet.

Integrity screen: passed (3 checks) Checked 17 August 2026. Valeriya Malysheva, Helen Ray-Jones et al., High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk Read the source

Nature·5 August 2026

Sara G. Pelaz, Katsukuni Mitsui et al.

In mice, fixing shrunken cell antennas in the brain's fear center eased stress behaviors.

Brain support cells called astrocytes have tiny hair-like antennas called primary cilia. In stressed mice, these antennas shrink inside a brain area called the amygdala, which controls fear and emotion. Fixing these antennas with a targeted drug signal restored their length and improved stress-related behaviors. Similar antenna genes were active in human amygdala astrocytes, and some were disrupted in people with stress-related brain disorders.

What it could change Restoring shrunken cell antennas in stressed mouse brains improved stress-related behavior.

Shows a possible new brain target for stress disorders, tested only in mice so far.

Mice only, no human treatment tested yet.

Integrity screen: passed (3 checks) Checked 17 August 2026. Sara G. Pelaz, Katsukuni Mitsui et al., Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours Read the source

Nature Human Behaviour·3 August 2026

Marco Gui, Chiara Respi et al.

Joining social media before grade 9 lowered later test scores in Italian, English and math.

Kids who joined social media in grades 6 to 8 later scored lower on standard tests. Kids who waited until grade 9 or later scored better. The study followed 5,227 students in northern Italy, checking scores in Italian, English and math over time. Heavy smartphone use at key times of day seems to explain much of this gap.

The number 5,227 students

The number of students in northern Italy whose social media timing and test scores were compared.

One region in Italy, observational data, not a controlled trial.

Integrity screen: passed (3 checks) Checked 17 August 2026. Marco Gui, Chiara Respi et al., Longitudinal effect of early social media use on standardized learning outcomes during school career Read the source

10 more papers are in the full issue.

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Nature Nanotechnology·6 August 2026

Cenk O. Gurdap, Dunya Aydos et al.